Category Archives: HSCT

HSCT for Relapse Remitting Multiple Sclerosis – Phase 3 Clinical Trial

Here is the direct link from ClinicalTrials.gov to (MOST) – Maximizing Outcome of Multiple Sclerosis Transplantation.
This is the study, run by Dr. Richard Burt, that is currently recruiting people ages 18-58 with RRMS (Relapse Remitting Multiple Sclerosis) at Northwestern in Chicago, Illinois.
You will be able to see and read about all the criteria necessary to apply to the study as well as the protocol and contact information.

https://clinicaltrials.gov/ct2/show/study/NCT03342638


Study Description

Brief Summary:
Multiple sclerosis (MS) is at onset an immune-mediated demyelinating disease. In most cases, it starts as a relapsing-remitting disease with distinct attacks and no symptoms between flares. Over years or decades, virtually all cases transition into a progressive disease in which insidious and slow neurologic deterioration occurs with or without acute flares. Relapsing-remitting disease is often responsive to immune suppressive or modulating therapies, while immune based therapies are generally ineffective in patients with a progressive clinical course. This clinical course and response to immune suppression, as well as neuropathology and neuroimaging studies, suggest that disease progression is associated with axonal atrophy. Disability correlates better with measures of axonal atrophy than immune mediated demyelination. Therefore, immune based therapies, in order to be effective, need to be started early in the disease course while MS is predominantly an immune-mediated and inflammatory disease. While current immune based therapies delay disability, no intervention has been proven to prevent progressive disability. The investigators propose a randomized study of autologous unmanipulated peripheral blood hematopoietic stem cell transplant (HSCT) comparing two different conditioning regimens: (1) cyclophosphamide and rabbit anti-thymoglobulin (rATG) versus (2) cyclophosphamide, rATG, and Intravenous Immunoglobulin (IVIg).

Another HSCT article

There continue to be more articles coming out regarding the success and efficacy of HSCT for Multiple Sclerosis!

34th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) 2018.
Abstract 230, presented October 11, 2018.

I’ll make sure to update my Articles for HSCT

Gathering HSCT articles

I have a new page, featuring HSCT related articles that I will be updating as often as I find new articles that we can read to educate ourselves and others about HSCT.

Click here for the Page: Articles About HSCT

On your computer, you can find it above to the right, next to my About Me Page.
On your phone, you can find it in the Menu area on the upper left.